Dr. Lily Houghton recruits the witty and irreverent skipper Frank Wolff to navigate the treacherous waters of the Amazon in his rundown boat. Their quest centers on finding a legendary tree believed to possess extraordinary healing properties—an incredible discovery that could revolutionize medicine as we know it. As they journey deeper into the jungle, they encounter a host of challenges, including wild animals, treacherous terrain, and rival treasure hunters. Along the way, Lily and Frank develop a unique bond, blending their contrasting personalities and skills to overcome obstacles. This adventure promises not only to uncover ancient secrets but also to transform their lives in unexpected ways.