When 11-year-old Riley relocates to a new city, her emotions—Joy, Fear, Anger, Disgust, and Sadness—join forces to guide her through the challenges of adjusting to her new life. However, when an unexpected turn of events causes Joy and Sadness to become separated from the rest of the team, they embark on a journey through unfamiliar and unpredictable areas of Riley’s mind. In a race against time, the two emotions must navigate this strange mental landscape and find their way back home before Riley’s world is turned upside down. Along the way, they learn important lessons about emotions, growth, and the complex nature of change.